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National Institutes of Health (NIH Publication No

We found that similar as the approved medication Pirfenidone, FOXO4DRI decreased senescent cells, downregulated the expression of senescenceassociated secretory phenotype (SASP) and attenuated BLMinduced morphological changes and collagen deposition

While these side effects may come across as quite alarming, its essential to remember that not everyone will experience them

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations Angptl4 Angiopoietin-Like 4 bLPL bovine LPL BSA Bovine Serum Albumin CVD cardiovascular disease CXN calnexin EL endothelial lipase ER endoplasmic reticulum fAngptl4 full-length Angptl4 FFA free fatty acids GPIHBP1 glycosylphosphatidylinositol-anchored high-density lipoproteinbinding protein 1 HDX-MS Hydrogen Deuterium Exchange Mass Spectrometry HL hepatic lipase HR heparin release HTG hypertriglyceridemia KRP Krebs Ringer Phosphate LMF1 lipase maturation factor LPL lipoprotein lipase nAngptl4 N-terminal domain Angptl4 PC proprotein convertase PHP post-heparin plasma SorLA sortilin-related receptor with type-A repeats TG triglyceride TRL TG-rich lipoproteins VLDL very-low density lipoproteins

Within minutes, the vast majority is degraded and cleared

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