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A recent proteomic study suggested altered mitochondrial function in the cerebrovasculature isolated from deceased cognitively healthy E4 carriers compared to non-E4 carriers, indicating that cerebrovascular bioenergetics may indeed be altered in cognitively healthy E4 carriers (Ojo et al., 2021)

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However, phenobarbital is effective and perhaps underutilized: Phenobarbital (15 mg/kg) was found to be equally effective as compared to lorazepam (0.1 mg/kg) as first-line therapy for status epilepticus in the VA-Cooperative trial

A healthy gut microbiome can reduce systemic inflammation, leading to clearer skin

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Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery