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10.1097/prs.0000000000009247 48 GouS.ZhuT.WangW.XiaoM.WangX

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Within 10 years of T2DM diagnosis, 24.9% of people develop microalbuminuria, 5.3% develop macroalbuminuria, and 0.8% develop advanced CKD that includes persistently elevated plasma creatinine or the need for renal replacement therapy [4]

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In rodent models, peripheral administration of exendin-4 (EX4), a GLP-1RA has been shown to reduce motivation for sucrose, as evidenced by decreased responding in progressive ratio operant-conditioning tasks (Dickson et al., 2012)

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