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While taking ibuprofen with semaglutide is generally considered safe for occasional use, the slowed stomach effect of your treatment means you should be more mindful of how and when you take NSAIDs

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Persistent or severe gastrointestinal symptoms while on GLP-1 therapy, such as severe nausea, vomiting, diarrhea, or severe abdominal pain, should prompt immediate medical evaluation

In large-scale clinical trials for tirzepatide, participants were generally instructed to take their dose on the same day each week, but the specific hour was not a strictly controlled variable

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