Constipation is severe and unresponsive to multi-modal management
Increases energy, supports fat loss, and enhances mitochondrial efficiency
Over the past few years, two injectable medicines have stood out in the fight against obesity Semaglutide and Tirzepatide
Abbreviations PCOS: Polycystic ovary syndrome SHBG: Sex hormone binding globulin FSH: Follicle-stimulating hormone COX-2: Cyclooxygenase 2 CRP: C-reactive protein TNF: Tumor necrosis factor alpha NF-B: Nuclear factor kappa B LH: Luteinizing hormone AR: Androgen receptor DHT: Dihydrotestosterone AMPK: AMP-activated protein kinase GLUT-4: Glucose transporter type 4 IRS: Insulin receptor substrate EGCG: Epigallocatechin gallate SOD: Superoxide dismutase Nrf2: Nuclear factor erythroid 2related factor 2 GPx: Glutathione peroxidase Arg: Arginine Cur: Curcumin CAT: Catalase MDA: Malondialdehyde NAcHis: N-acetyl histidine Bcl-2: B-cell lymphoma 2 DHEA: Dehydroepiandrosterone HFD: High-fat diet PCOS: Polycystic ovary syndrome PPAR: Peroxisome proliferator-activated receptor MAPK: Mitogen-activated protein kinase PCNA: Proliferating cell nuclear antigen cAMP: Cyclic adenosine monophosphate CYP: Cytochrome p450 enzyme FSH: Follicle stimulating hormone LDL: Low-density lipoprotein PCOS: Polycystic ovary syndrome TG: Triglycerides References Guastella E, Longo RA, Carmina E
Why Injection Site Rotation Matters Rotating injection sites between weekly doses prevents lipodystrophy, a condition where repeated injections in the same spot cause local fat tissue changes
He patented the idea and soon afterwards a biotech company called Amylin Pharmaceuticals to begin the work of turning exendin-4 into a drug for diabetes
