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A notable safety signal is dysaesthesia, which refers to tingling, numbness, or altered skin sensations, reported in about 1 in 5 participants at the 12 mg dose

doi:10.1016/j.amjoto.2014.06.009

Taken together, the available evidence positions BCAA supplementation as a disease-modifying nutritional intervention in advanced cirrhosis, with benefits operating through the three converging mechanisms outlined in Section 3.3.2: Fischer ratio correction, skeletal muscle ammonia clearance support, and mTORC1-mediated promotion of hepatocyte proliferation and protein synthesis

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Ann Rheum Dis, 2004