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Per a 2019 article in the Annals of Allergy, Asthma, & Immunology, it is difficult to quantify exactly how many people develop allergies to monoclonal antibodies, mostly because there are many different types, each unique in composition

Zhang W, Doherty M, Bardin T, et al

In these patients, mixed agonist/antagonist and partial agonist analgesics may reduce the analgesic effect and/or precipitate withdrawal symptoms (see PRECAUTIONS, Drug Interactions)