Adelson Medical Research Foundation to N.D.U
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Normally, antioxidant enzymes (SOD, CAT, GPx) neutralize free radicals such as hydrogen peroxide
The natural compound T1 isolated from Gastrodia elata shows outstanding inhibitory potency against tyrosinase (IC 50 = 0.53 M, K i = 58 6 nM), which is more effective than -arbutin, kojic acid, short peptides 74,75 and other known natural compounds (Supplementary Table S1)
Co-immunoprecipitation (Co-IP) analysis revealed a decrease in the ubiquitination level of Keap1 in db/db mice, which resulted in Nrf2 depletion
Future investigations could explore novel therapeutic avenues from the synovium and subchondral bone perspectives