Retatrutide appears to have more average weight loss (24.2%) vs
Practical factorssuch as insurance coverage, approved indication (type 2 diabetes vs obesity), drug availability, previous side effects, and co-existing health conditionsusually matter more than subtle mechanistic differences when deciding which medication to use and how aggressively to dose it

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Another recent study using an even more specific method to detect (and rule out) GLP-1 receptors in tissues (a radioligand assay) did not confirm GLP-1 receptors in human thyroid tissue outside C cells (35)
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Accessed March 30, 2026