This classic sign typically appears in severe, prolonged iron deficiency Brittle nails : Increased fragility with splitting, peeling, or easy breakage at the free edge Pallor of the nail bed : The normally pink nail bed appears pale or white due to anaemia Vertical ridging : Longitudinal lines or grooves running from cuticle to tip, though these are also common with ageing and may not indicate deficiency Slow growth : Reduced nail growth rate compared to normal (approximately 3mm per month), though this is non-specific and occurs with ageing Nail changes occasionally associated with B12 deficiency include: Blue-grey or brown hyperpigmentation : Diffuse darkening of the nail plate, though this is rare Longitudinal melanonychia : Dark vertical bands, particularly in darker-skinned individuals Brittle texture : Similar to iron deficiency, with increased fragility Nail plate thinning : Overall reduction in nail thickness IMPORTANT : A new or changing dark band on a single nail requires urgent medical assessment, as this may indicate subungual melanoma (a form of skin cancer) rather than nutritional deficiency
Antecedente de pancreatitis aguda Antecedente de Neoplasia endocrina multiple 2
CPPsite 2.0: a repository of experimentally validated cell-penetrating peptides
Oral and sublingual B12 supplements are readily available, but the general consensus is that intramuscular injections of B12 are the most effective and efficient means of delivery
For weight management, NICE recommends semaglutide 2.4mg (Wegovy) for adults with a BMI 35 kg/m (or 30 kg/m with weight-related comorbidities) within specialist weight management services alongside lifestyle interventions (TA875)
OstroVit L-Carnitine Shot is the diet supplement in a form of liquid
