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These proteins consist of transmembrane (occludin, claudin, junctional adhesion molecules, and tricellulin) and cytoplasmic proteins (zonula occludens, cingulin, and afadin), which help coordinate the alteration of the cytoskeleton (23)

Lipid peroxidation, GPX4 inhibition, and iron accumulation lead to ferroptosis, resulting in an abnormal accumulation of fibrotic lesions in the tissues, which promotes tissue and organ fibrosis 30

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