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For patients who discontinued treatment during the study period, we used the day of treatment discontinuation (defined as the estimated end date of the most recent prescription plus the grace period of 90 days) as the start of follow-up to assess treatment reinitiation, defined as the first new prescription of the drug class that had previously been discontinued

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While astrocytes were historically considered to appear morphological changes in response to injury, trauma, aging, and neurodegeneration (Stephenson et al., 1999