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A variety of receptors regulating bile duct metabolism, such as PPAR and farnesoid-X receptors (FXR), appear to play a crucial role in disease pathogenesis, making them attractive targets for disease-modifying drugs ( Figure 2 3 Available treatment options 3.1 Current treatment regimens 3.1.1 Ursodeoxycholic acid UDCA has been the cornerstone of PBC treatment since its approval in 1994

The timing remains similar to injection protocols (1-3 hours before activity) with possibly 30-45 minute faster onset due to direct mucosal absorption

Studies have observed users regularly opt for smaller portions, with less desire for high-fat, high-energy, non-sweet foods