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Initiated biologics included in this analysis were adalimumab, certolizumab, etanercept, infliximab, ustekinumab, secukinumab, ixekizumab, brodalumab, bimekizumab, guselkumab, risankizumab, tildrakizumab, and available biosimilars (adalimumab, etanercept, and infliximab)

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Critically, in non-senescent cells, this interaction is not a survival dependency, so FOXO4-DRI does not trigger apoptosis in healthy cells