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[4] In the SURMOUNT-1 obesity trial, a 72-week placebo-controlled study in 2,539 adults with obesity (without diabetes), mean weight change was 15.0%, 19.5%, and 20.9% at the 5, 10, and 15 mg doses versus 3.1% for placebo

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One clinical study found that these tend to be mild to moderate, occurring primarily when dosage levels increased from 5 mg to 10 mg/15 mg

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When to Speak to a Professional It is important to remember that changes in skin pigmentation can sometimes be a sign of underlying health issues