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Exposure-response analysis for evaluation of semaglutide dose levels in type 2 diabetes

These include: Nausea (the most common complaint, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment or following a dose increase

2012;43(3):e11-e18

But small human studies suggest that yerba mate, or green mate (which contains the same active compound), may help with fat loss and appetite reduction

2 TRIUMPH-1 is the larger, longer trial that confirms those earlier results