The patients must be encouraged to follow the specific recommendations to avoid/mitigate diarrhoea (Table 2, Figure 1, Figure 2 and Figure 3), which should already have been taught to them as part of their education prior to GLP-1 RA initiation
It can pass easily to the brain and is both water and fat-soluble Liu and colleagues tested aged rats with oral acetyl-L-carnitine and lipoic acid to see if the supplementation reduced mitochondrial aging in the brain [1] A group from Oregon State University reviewed the literature and suggested that together, acetyl-L-carnitine and lipoic acid were able to protect the heart from aging as well as reverse age-related changes [2]
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One unique aspect of treating paediatric RD is the necessity of also treating the amblyopia in the affected eye post-operatively to maximize the vision gains 22
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155 A meta-analysis of trials in elderly subjects with mild cognitive impairment found B12 plus folate lowered homocysteine and improved cognitive function more than either nutrient alone
