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Deficiency of Thiamine can result in nerve disorders

B vitamins are proven cofactors in energy metabolism

elevated triglycerides (defined as 150 mg/dL), decreased High Density Lipoprotein (HDL) (ranges below 40 mg/dL in men and 50 mg/dL in women), elevated blood pressure (defined as systolic blood pressure above 130 mmHg or diastolic blood pressure above 85 mmHg) and elevated fasting glucose (defined as blood glucose above 100 mg/dL)

J Park Dis 11:949970 Martin A, Youdim K, Szprengiel A, Shukitt-Hale B, Joseph J (2002) Roles of vitamins E and C on neurodegenerative diseases and cognitive performance

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To find out whether a B12 shot will help relieve your chronic problems with fatigue, lets examine what a vitamin B12 deficiency is, how it leads to fatigue, and how much B12 you need to stay healthy