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To gain deeper insights into the impact of the conjugate on both the brainstem and the mesolimbic reward system, we conducted complementary transcriptomics analyses (Extended Data Fig

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Two emerging pharmacological classes may challenge its risk-reward calculus: Oral GLP-1 agonists (e.g., oral semaglutide, danuglipron): These offer dosing convenience and eliminate injection site reactions, but bioavailability remains problematic (oral semaglutide achieves only 0.41% absorption, requiring daily dosing and strict administration protocols)