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As summarized in Table 2, preclinical studies in aged animal models revealed a potential relationship between dosing strategy, route of administration, and neurological outcomes

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In practice, TB-500 remains outside FDA-sanctioned compounding and is sold only as an unregulated research chemical

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Persico AM, Bourgeron T

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It is also well known that high reactivity, longer circulation time, off-target nanomaterial accumulation, and unintentional exposure are the main risks of NP toxicity (Johnston et al., 2010