Brand-Name Alternatives Brand-name semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are manufactured by pharmaceutical companies and distributed through traditional pharmacies, but their costs often exceed $900$1,400 per month even with insurance coverage
GLP-1 specifically binds to the glucagon-like peptide-1 receptor (GLP-1R) in the body, directly stimulating the secretion of insulin by pancreatic -cells, promoting proliferation and differentiation, and inhibiting cell apoptosis, thereby exerting a glycemic lowering effect
CD38 CD38 is a multifunctional enzyme involved in NAD + metabolism and intracellular signaling (Xie et al
GLUCOSE-LOWERING TREATMENT Evidence indicates that improved glycaemic control defers the onset and reduces the progression of microvascular complications in diabetes
Experimental protocol Using a previous procedure and regimens (10-12), BPC 157 was given perorally, in drinking water (10 g/kg, 10 ng/kg, i.e., 0.16 g/mL, 0.16 ng/mL, 12 mL/rat/day) till sacrifice, or alternatively, 10 g/kg, 10 ng/kg intraperitoneally, first application at 30 min after surgery, last at 24 hours before sacrifice
Peptide therapy should only be used under the guidance of a licensed medical provider
