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Preclinical and limited human studies indicate DSIP may modulate the hypothalamicpituitaryadrenal (HPA) axis and support healthy cortisol rhythms, making it of interest in stress-related sleep disruption

In our analysis, significant weight regain was observed only in the lower baseline BMI subgroups which did not conform to the common understanding, possibly because the enrolled patients were more severely obese and then not well differentiated by the BMI cutoff point, and the limited data in the analysis also reduced the confidence of the result

Prescribed or over-the-counter pain medications effectively manage discomfort, with most patients able to return to light, non-strenuous activity in two to three days

Overall, as GLP-1RAs become increasingly prescribed, further pharmacovigilance studies are warranted, noted the authors

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