Concurrent dosing reduces efficacy by creating NAD+ demand spikes and competitive receptor saturationtiming separation is the critical variable for synergy
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This is consistent with the methyl folate trap hypothesis (54), which predicts that, in vitamin B-12 deficiency, the inhibition of DNA synthesis and cell proliferation is removed upon administration of high doses of folic acid because of increased availability of nonmethylated folate
Low B12 levels may lead to tiredness, weakness, cognitive difficulty, or numbness and tingling in the extremities
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