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The current review focuses on Se transport to the brain, primarily including selenoprotein P/low-density lipoprotein receptor-related protein 8 (LRP8, also known as apolipoprotein E receptor-2) dependent pathway, and supplementary transport routes of Se into the brain via low molecular weight Se-species

Nat Commun 10 , 4567 (2019)

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It supplies vitamin B12 and Zn: vitamin B12 maintains myelin sheath integrity (preventing prefrontal cortex damage), while zinc modulates TPH1 activityboth deficiencies are associated with higher depression risk (306, 307)