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This distinction matters because the mechanism comes with inherent limitations: an initial worsening period (the retinoid purge lasting 4 to 8 weeks), ongoing irritation, dryness, and photosensitivity, and the inability to be used on actively wounded or compromised skin

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There are many signs and symptoms of autismsuch as trouble with communication and repetitive behaviors that manifest to varying degrees from person to person

McGowan says