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Cladribine's main adverse effects documented from the cancer studies, included significant immunosuppression associated with opportunistic infections such as herpes simplex, paresthesias, and possible secondary malignancy (149)

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

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