With a sample of 1,014 subjects (789 simvastatin users, 225 atorvastatin users) from the Rotterdam study, they reported that the number of dose reduction or statin switching events significantly ( p = 0.045) increased with the number of A alleles
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Efficient GST activity and adequate glutathione are thus important for neutralizing patulin.[ref] Overall, combinations of slower CYP1A2/CYP3A4 alleles with reduced-function GST or UGT variants can leave someone more vulnerable at normal dietary exposure levels, because reactive mycotoxin intermediates may not be cleared efficiently
the Ministry of Science, Innovation and Universities, Spain (Grants RYC-2014-15581, AGL2016-81890-REDT, AGL2017-88329-R and FJCI-2017-31689)
