The convergence of bile acid-FXR/TGR5 signaling, microbial metabolite-driven adipocyte gene programs, and central neuroendocrine control establishes a microbiota-gut-brain-adipose axis through which GLP-1RAs support healthy AT remodeling, WAT beiging, and overall metabolic balance [144,145]
Theiss HD, Brenner C, Engelmann MG, Zaruba MM, Huber B, Henschel V, Mansmann U, Wintersperger B, Reiser M, Steinbeck G, et al: Safety and efficacy of SITAgliptin plus GRanulocyte-colony-stimulating factor in patients suffering from Acute Myocardial Infarction (SITAGRAMI-Trial)rationale, design and first interim analysis
doi: 10.1055/s-0031-1271777 49 Ben NasrMUsuelliVDellepianeSSeelamAJFiorentinoTVDAddioFet al
Patients should be advised to contact their GP or prescribing clinician promptly if they experience any new or worsening cardiovascular symptoms
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The Cochrane Collaboration