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In addition, chronic stimulation of VANs reduces food intake and weight gain in rats 45,46,47 and is associated with weight loss in humans 48 , highlighting the long-term physiological relevance of vagal signaling

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GLP-1 helps keep blood sugar steady and reduces hunger

They work in the gut like the bodys natural GLP-1, slowing digestion, curbing hunger, and signaling fullness to the brain

38 GLP-1RAs increase microvascular blood flow in muscle tissue, enhance myocyte metabolism, inhibit muscle atrophy, and improve muscle mass and function

Lets delve into the mechanics of how GLP-1 agonists facilitate weight loss