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Tirzepatide preserved cardiac function following one week of continuous angiotensin II induction To characterize the effects of tirzepatide and liraglutide on angiotensin II-induced cardiac morpho-functional changes, echocardiography was performed at baseline, after one week of continuous AngII infusion and before termination at week of the treatments

Nutr Metab Cardiovasc Dis 2022;32:2279-2288

"There seems to be a broad range of sensitivity to the medications among different people." In practical terms, that means a lower dose may still help with appetite, food noise and weight loss but results may be slower, less predictable or insufficient compared with the regimens that have actually been studied

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This directly addresses the concern about semaglutide and muscle loss

This is why Klinics metabolic health program focuses on branded medications like Zepbound that can be monitored through telehealth and are more often covered for weight management purposes