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In adjusted analyses, semaglutide reduced epigenetic aging across multiple second- and third-generation clocks, including PhenoAge ( 4.9 years/year, p = 0.004), PCGrimAge ( 3.1, p = 0.007), GrimAge V2 ( 2.3, p = 0.009), OMICmAge ( 2.2, p = 0.009), RetroAge ( 2.2, p = 0.030), and DunedinPACE ( 0.09 units, 9% slower, p = 0.01)

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Regular physical activity, including low impact aerobic exercise and strength training, helps preserve joint function, improve biomechanics, and reduce pain, he added

Neuroimmunology of traumatic brain injury: time for a paradigm shift

For an adult who is 5 foot 8 inches tall, that's a weight of 197 pounds or more