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However, whether appendicitis and appendectomy cause colorectal cancer (CRC) is controversial

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The standard dosing schedule is: Weeks 14 : 0.25 mg once weekly (initial dose) Weeks 58 : 0.5 mg once weekly Weeks 912 : 1 mg once weekly Weeks 1316 : 1.7 mg once weekly Week 17 and onward : 2.4 mg once weekly (maintenance dose for adults and pediatric patients aged 12 years and older) This gradual increase reduces the risk of side effects like nausea and ensures the body adapts to the medication

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Under current US compounding rules, pharmacies and outsourcing facilities may only compound medicines using active pharmaceutical ingredients (bulk drug substances) that form part of an FDA-approved medicine, appear in an official United States Pharmacopeia or National Formulary monograph, or are included on the FDAs bulk drug substance list

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