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The effect of DPP-4 inhibitors, GLP-1 receptor agonists and SGLT-2 inhibitors on cardiorenal outcomes: a network meta-analysis of 23 CVOTs

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Nutrients , 11 (5), 952

Insulin and leptin levels drop precipitously, both of which have downstream effects on follicular health

2014, 13:142 GLP-1R Signaling Binding of GLP-1 to GLP-1R triggers a downstream signaling cascade that induces a potent stimulation of glucose induced insulin secretion (GIIS) in pancreatic beta-cells, as well as inhibition of alpha cell glucagon release (6)