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One explanation for these observations may be the HbA1c levels at baseline and the rapidity of reduction of HbA1c, considering that rapid improvement in glucose control has been associated with aggravated diabetic retinopathy (77-79)

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Conclusion: These findings indicate the importance of TonEBP expression, modulated by SGLT2 inhibitors, as a crucial molecular regulator in the renal protective effects against cellular senescence

Similarly, some animal studies have found protective effects of TMAO on CVDs

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