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The ongoing accumulation of hepatic triglyceride may represent a compensatory measure implemented to convey some degree of protection against more harmful lipid species

A skin sensitivity test prior to administration is advised

Each pathway below is backed by measurable outcomes in large trials like SURPASS-4 (type 2 diabetes with cardiovascular risk) and SUMMIT (heart failure with preserved ejection fraction, many with CKD)

Originally used as a diabetes drug because of its ability to lower blood sugar levels, semaglutide for weight loss was approved by the Food and Drug Administration in 2021 after drug manufacturers found that it also helped patients feel fuller and eat less

While it is unclear what Lilly will do in light of this development, we expect some if not most compounders will see this as an opportunity for at least temporarily continuing to compound tirzepatide