Future work should focus on 3D cultures and in vivo animal models that more accurately mimic a natural cellular environment, allowing a true evaluation of the peptides effectiveness as an anti-aging compound
Use caution in a patient with a history of anaphylaxis or angioedema with another GLP-1 receptor agonist because it is unknown whether such patients will be predisposed to these reactions with SAXENDA
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The companion finding of a significant 16% all-cause mortality reduction with tirzepatide and benefit on the expanded 4-point MACE endpoint suggests that additional risk reduction may exist but is more diffusely distributed than the 3-point MACE composite captures [6]
