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ROS are produced in response to a variety of stimuli, such as ultraviolet radiation, cigarette smoke, alcohol, nonsteroidal anti-inflammatory drugs, and infections

TABLE 1 Possible benefits and drawbacks of surgical and pharmacological interventions

Additionally, ethical considerations regarding its use as a skin-bleaching agent must be addressed to avoid reinforcing structural racism and healthcare disparities

Protein kinase R-like ER kinase (PERK) is the main sensor of ER stress

Given these challenges, there is a growing consensus around the need for multimodal approaches to neuroprotection in PD

doi:10.1002/jcp.22571, PMID: 21660956 Guha P, Dey A, Sen R, Chatterjee M, Chattopadhyay S, Bandyopadhyay SK (2011) Intracellular GSH depletion triggered mitochondrial Bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line