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The evidence is still evolving, but heres what we know so far

it also triggers hormonal changes (independent of GLP-1 drugs) that reset metabolism, reduce appetite, and often lead to the remission of type 2 diabetes

Intestinal Problems: Feelings of sickness, vomiting, and stomach cramps were reported

The NK1-receptor antagonist NKP608 has an antidepressant-like effect in the chronic mild stress model of depression in rats

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First week: Mild nausea, fatigue, or headaches are most common Weeks 24: Symptoms often lessen as the body adapts After one month: Many people report minimal or no ongoing side effects Side effects may briefly return after dose increases, then improve again