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[4] Richie JP, et al

FIGURE 8 Atherosclerosis, a chronic inflammatory disease, may be an ideal environment for the high viral replication capabilities of SARS-CoV-2 in human cells, enhancing hyper-inflammation secondary to immune system dysregulation (Figure 9) that leads to adverse outcomes, as shown in patients with cardiovascular risk factors (258, 259)

Some people describe it as their skin "looking angry" without obvious cause

Dhillon (2002)

If concomitant use is warranted, consider prescribing an opioid overdose reversal agent [see WARNINGS, DOSAGE AND ADMINISTRATION, OVERDOSAGE]

[DOI] [PubMed] [Google Scholar] 45.Ghanizadeh A, Derakhshan N, Berk M