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Phase I trials confirmed consistent pharmacokinetics and tolerability, while Phase II trials identified 0.5 mg and 1.0 mg once weekly as the most effective doses

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Accumulation of ketone bodies in the blood vessels induces neutrophilic inflammation (239)

Participants were then classified into three groups: (1) control participants who remained controls (Con-Con), (2) participants with migraine who continued to have migraine (Mig-Mig), (3) initially control participants who now experience migraine (Con-Mig)