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High-throughput microscopy and quantitative analysis Images of wells from 96-well plates were acquired using the IN Cell Analyser 2500HS high-throughput microscope and plate reader (Cytiva)

Early trial data shows weight loss exceeding 24% at higher doses

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Additionally, vitamin B12 deficiency can cause neurocognitive manifestations including depression, episodes of psychosis, delirium, dementia, poor memory performance, and cognitive impairment ( In 1978, Carney and Sheffield found that 31% of patients suffering from depression had low serum vitamin B12 levels (65)

( D ) Mean relative PPP Flux in H441 cells treated with DMSO control or 1 M KEAPi (Davies et al, 2016) for 48 h and labeled with [1,2- 13 C]-glucose for 14.5 h

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