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Acknowledgements We are grateful to Sofie Lsch and Ines Otte for technical assistance

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DOI: 10.1007/s11481-008-9121- Keywords MDMA (ecstasy, X, Molly) Drug Class: Drug of Abuse: CNS Stimulant & hallucinogen Street Names: Molly (for molecule), Mandy (in the UK), E, X, XTC Mechanism of Action: Similar mechanism as amphetamine, but with a preferential effect on SERT, and thereby strongly increases the extracellular concentration of serotonin

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The interactions of oxyntomodulin differed, with more transient contacts deep within the peptide binding cavity and with residues located higher within TM2, and with ECL2