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Results at 72 weeks: Placebo: 3.1% weight loss Tirzepatide 5 mg: 16.0% weight loss (35.3 pounds average) Tirzepatide 10 mg: 21.4% weight loss (49.7 pounds average) Tirzepatide 15 mg: 22.5% weight loss (52.3 pounds average) The percentage of participants achieving 5% or more weight loss was 89% (5 mg), 96% (10 mg), and 96% (15 mg)

Semaglutide Common side effects may include: Nausea Vomiting Diarrhea Abdominal pain Constipation Heartburn Burping More severe side effects that require immediate medical attention: Ongoing upper stomach pain (with or without vomiting) Rash, itching, or swelling of the eyes, face, mouth, tongue, or throat Difficulty breathing or swallowing Decreased urination or swelling of legs, ankles, or feet Vision changes Fainting or dizziness Rapid heartbeat, anxiety, mood changes, or confusion Semaglutide may affect mental health, leading to symptoms such as depression or suicidal thoughts

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It involves weighing several critical factors, each with its own ripple effect on your research project: Research Goals and Endpoints: Are you looking for a sustained, moderate effect over a long period, or a rapid, potent peak concentration

Additionally, a post-hoc compiler average causal effect analysis was performed to estimate the influence of treatment adherence on outcomes