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Intentionally slowing normal metabolism can cause cardiovascular complications, endocrine disruption, iatrogenic hypothyroidism, and metabolic syndrome

doi: 10.1097/WNF.0000000000000299 231 Varela-TrinidadGUDomnguez-DazCSolrzano-CastanedoKiguez-GutirrezLHernndez-FloresTDJFafutis-MorrisM

Only those who reached the maintenance dose and completed that phase were randomised to continue semaglutide or switch to placebo, with lifestyle intervention in both arms

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Triggering and modulation of apoptosis by oxidative stress

The lipidation step, common to both semaglutide and tirzepatide, adds an additional layer of chemical complexity