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Sleep deprivation affects the balance of hunger-regulating hormones, leading to increased appetite and cravings for calorie-dense foods

Comparators were control groups receiving either standard care or placebo, which allows for robust comparison of the therapeutic efficacy of SGLT2Is in reducing cardiovascular events

GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA

But getting access to them safely, affordably, and with proper medical oversight has always been the challenge