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Common gastrointestinal side effects are the most frequently reported adverse reactions, particularly during treatment initiation and dose escalation: Nausea (affecting 2040% of patients initially) Vomiting and diarrhoea Constipation Abdominal discomfort or bloating These symptoms typically diminish over several weeks as tolerance develops

Typische Symptome sind anhaltende, starke Bauchschmerzen

Avoid strongly alkaline conditions that can compromise the C-terminal amide

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