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10.1111/jocd.14202 J Cosmet Dermatol

doi:10.1186/s12958-018-0323-4

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R747W is a mutant phenotype with loss-of-function of the gene encoding iPLA2, which reduces the hydrolytic activity of 15-HpETE-PE, and increases the content of 15-HpETE-PE in cells, and increases the sensitivity to ferroptosis compared with the wild type