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(37552484) Risks of high-dose acetylcysteine Case reports describe toxicity (including hemolysis and cerebral edema) following dosing errors resulting in excessive administration of acetylcysteine (e.g., 5-fold increase in the first dose, or 10-fold increase in the maintenance doses)

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CaSR possesses binding sites for multiple ligands, which include orthosteric agonist, extracellular Ca 2+ , and many allosteric compounds, such as amino acids and peptides that include -glutamyl peptides [10,166]