1113 Two drug classes that significantly reduce major adverse cardiovascular events (MACE) and death, regardless of the presence of T2D, are sodiumglucose co-transporter inhibitors (SGLTis) and glucagon-like peptide-1 (GLP-1) receptor agonists (RAs)
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Diabetes Care 2015;38:12451252
In completed randomized trials, tirzepatide consistently achieves greater reductions in body weight and HbA1c compared with semaglutide, demonstrating the synergistic metabolic benefits of simultaneous GIP and GLP-1 receptor stimulation
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