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These modified proteins can be taken up by antigen-presenting cells (APCs), processed, and presented to T cells, leading to the activation of autoreactive T cells and the production of autoantibodies
Nassuato G, Iemmolo RM, Strazzabosco M, Lirussi F, Deana R, Francesconi MA,
But in other cases, imprinting can be positive, by promoting the development of cross-reactive antibodies that neutralize strains in both the initial and subsequent vaccines
Hsu, J.-W